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Model of interaction between HCMV IE1, hPML, and ICP0. HSV infection produces an immediate-early protein, ICP0, that degrades poly-SUMO-PML but not mono-SUMO-PML. HCMV immediate-early protein, hIE1, deSUMOylates hPML to generate mono-SUMO-PML, which cannot be degraded by ICP0. Therefore, hIE1 protects hPML from degradation by ICP0.
