FIG 12.

Acute reovirus infection is reduced in pIgR KO mice. Mice were infected by oral gavage with 2 × 10⁶ PFU/animal of reovirus T1L, and indicated tissues, i.e., mesenteric lymph node (A), duodenum (B), jejunum (C), ileum (D), cecum (E), colon (F), and feces (G), were harvested at 24 hpi. Viral titers in the indicated tissues of WT and pIgR KO mice were assessed via plaque assay. The data were pooled from two independent experiments, and each symbol is a data point from an individual animal. The error bars represent SEM. The data were analyzed using the Mann-Whitney U test. *, P < 0.05; **, P < 0.01; ns, not statistically significant.