FIG 6.

BART5-3p promotes tumor growth in the nude mice xenograft model. (A) Tumor growth curves of SGC7901 xenografts in nude mice (n = 6 each). Group 1, 2, and 3 mice were injected with LV-mock, LV-BART5-3p, and LV-BART5-3p cells, respectively (see Materials and Methods for details). The arrow indicates the first administration of BART5-3p antagomir in group 3 mice. (B, C) Xenograft tumors collected on day 30 following subcutaneous implantation. (D) The representatives of immunohistochemistry staining for p21 in tumors from xenograft nude mice. Original magnification, ×200; bar, 50 μm.