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. 2018 Nov 6;12:403. doi: 10.3389/fncel.2018.00403

Figure 2.

Figure 2

Effects of stimulatory and inhibitory ryanodine concentrations and of caffeine on fEPSP rise times, half-widths and decay constants tau measured in CA3–CA1 hippocampal synapses. Left panels: slices were treated with 1 μM ryanodine. (A) fEPSP rise times vs. stimulus intensity. (B) fEPSP half-widths vs. stimulus intensity; (C) fEPSP decay constants (tau) vs. stimulus intensity. Central panels: slices were treated with 20 μM ryanodine for 60 min. (D) fEPSP rise times vs. stimulus intensity; (E) fEPSP half-widths vs. stimulus intensity; (F) fEPSP decay constants (tau) vs. stimulus intensity. Right panels: slices were treated for 15 min with 1 mM caffeine. (G) fEPSP rise times vs. stimulus intensity; (H) fEPSP half-widths vs. stimulus intensity; (I) fEPSP decay constants (tau) vs. stimulus intensity. Values represent Mean ± SE; (12, 3). The first number in parentheses indicates the number of hippocampal slices and the second the number of animals used. Statistical significance of values was assessed Mann-Whitney test (*p < 0.05).