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Percent changes in patients with (A–C) early onset colon (ages 20–44 years) and rectal cancers (ages ≤54 years) and (D–F) later-onset colon and rectal cancers (defined as age ≥60 years old). Clinicopathological tumors characteristics include (A,D) cancer staging and tumor (B,E) histology and (C,F) grade. Staging based on a merging of AJCC 3rd and 6th editions from the time periods of 1988–1994 to 1995–2014. Error bars represent 95% confidence intervals.
