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Effect of LPS and MPTP on the A1 astrocytic phenotype in the striatum. Immunofluorescent double labeling of GFAP and C3 shows the absent of C3 immunostaining in non-reactive astrocytes present in the control striatum (A–C). A similar pattern was seen in the striatum of animals treated with LPS (D–F) or MPTP (G–I) alone. However, the combination of LPS and MPTP clearly induced the expression of A1 astrocytic phenotype in striatum (J–L). Scale bar: 100 μm.
