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. 2018 Nov 6;12:398. doi: 10.3389/fncel.2018.00398

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Copyright © 2018 García-Domínguez, Veselá, García-Revilla, Carrillo-Jiménez, Roca-Ceballos, Santiago, de Pablos and Venero.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of LPS and MPTP on the dopaminergic neurons. (A) Coronal section showing TH immunoreactivity in a control animal. (B) TH immunoreactivity 2 weeks after the injection of LPS. No significant changes are observed. (C) TH immunoreactivity 2 weeks after the injection of MPTP. There is a clear loss of dopaminergic neurons in the SN. (D) TH immunoreactivity 2 weeks after the injection of both LPS and MPTP. The loss of neurons is higher. Scale bar: 500 μm. (E) Quantification of the number of TH-positive cells. Results are mean ± SD of three independent experiments, and are expressed as TH-positive cells within the bounded area of the SN. Statistical signification (ANOVA followed by the LSD post hoc test for multiple comparisons): a, compared with control; b, compared with MPTP; p < 0.001.