Figure 3.
Synthesis of cap analogue 2 (i) 1. Cl3PNP(O)Cl2, (MeO)3PO, −8°C, 6 h; 2. H2O, NaHCO3; (ii) (CH3O)2SO2 (5 equiv.), H2O pH 4, 6 h; (iii) 0.5 M borate buffer pH 8.5, 1 h; (iv) ZnCl2 (8 equiv.), DMF, 8 h.
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