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3′ end tailing plays a fundamental role in small RNA quality control and turnover. Argonaute bound small RNAs are tailed at the 3′ end by terminal nucleotidyl transferases. In S. pombe Argonaute bound small RNAs uridylated or adenylated by the terminal nucleotidyl transferases Cid14 and Cid16 are actively removed from Argonaute and degraded by Rrp6. This small RNA turnover is necessary to protect the cells from uncontrolled RNAi.
