Table 1.

Orthologue proteins involved in nuclear RNA decay in S. cerevisiae, S. pombe and human cells.

S. cerevisiae		S. pombe		H. sapiens			main activity
protein	complex	protein	complex	protein	complex
Trf4 Trf5	TRAMP4 TRAMP5	Cid14	TRAMP	PAPD5 (TRF4-2) PAPD7 (TRF4-1)	TRAMP		non-canonical polyA-polymerase
Air1/Air2		Air1		ZCCHC7			RNA binding (zinc knuckle)
Mtr4		Mtr4		MTR4 (SKIV2L2)			helicase
		Mtl1	MTREC/NURS
—		Ars2		ARS2		CBCA	CBC binding
Sto1 (Cbp80)		Cbc1		CBP80	CBC		cap-binding complex large subunit
Cbp20 (Cbc2)		Cbc2		CBP20			cap-binding complex small subunit
—		—		ZCCHC8	NEXT (with MTR4)		zinc finger; linker between MTR4 and RBM7
—		—		RBM7			RNA binding (RNA recognition motif)
—		—		ZC3H18	—		RNA binding (zinc finger); linker between CBCA and NEXT or PAXT
—		Red1		ZFC3H1	PAXT (with MTR4)		RNA binding (zinc finger)
Sgn1		Pab2		PABPN1		PPD	pA RNA binding (RNA recognition motif)
Pap1		Pla1		PAPOLA/G			canonical polyA polymerase
—		Rmn1		Rbm26/27			pA RNA binding (RNA recognition motif)
—		Red5		ZC3H3			RNA binding (zinc finger)
—		Iss10		—			associates with meiotic transcripts
Pho94		Mmi1		YTHDF1/2/3			YTH domain
—		Ctr1		CCDC174			telomerase regulatory factor Ctr1
—		Nrl1		NRDE2			spliceosome-associated protein Nrl1
Hrp1		Msi2		MSI1/2			mRNA cleavage factor complex subunit (predicted in human)
Nrd1	NNS	Seb1		SCAF4 SCAF8			RNA binding (RNA recognition motif), Rpb1 binding: CTD-S5P in S. cerevisiae and CTD-S2P in S. pombe and human
Nab3		Nab3		RALY/RALYL HNRNPC/HNRNPCL1/2/3/4			RNA binding (RNA recognition motif)
Sen1		Sen1		SETX			helicase
—		Cid12	RDRC	—			non-canonical polyA-polymerase
—		Hrr1		ZNFX1			Hrr1: helicase ZNFX1: RNA binding (zinc finger domain)
—		Rdp1		—			RNA-directed RNA polymerase
Nab2		Nab2		ZC3H14			RNA binding (zinc finger domain) interaction with nuclear porines