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Survival analysis of F10 and Chk1 inhibition by prexasertib.
Colony survival assay performed in (A) HCT-116 cells shows decreased survival of Chk1i-treated colonies co-treated with F10 compared to DMSO-treated cells co-treated with F10. (B) Western blot analysis shows decreased pChk1-317 and increased γH2AX in the combination in HCT-116 cells. Similar to PF-477736, decreased expression of Rad51 and ubiquitination of FANCD2 were observed in prexasertib-treated cells too.
