Fig. 1.

Representative images showing HIF-1α expression in normal pancreas specimens and in pancreatic cancer specimens. Immunohistochemical staining of normal pancreas specimens for HIF-1α. A, the euglycemic group and B, the hyperglycemic group; C, D, and E show different expression levels of HIF-1α in pancreatic cancer specimens. C, a low expression level of HIF-1α (+), D, an intermediate expression level of HIF-1α (++) and E, a high expression level of HIF-1α (+++). (HIF-1α antibody concentration 1:200; 200× magnification).