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The effect of hyperglycemia on the normal pancreas. To induce hyperglycemia, 175 mg/kg STZ was injected into the peritoneal cavity of each mouse. Mice were sacrificed after 8 weeks. The H&E staining and transmission electron microscopy showed the morphology changes in the pancreas (A, C, the euglycemic group and B, D, the hyperglycemic group). Immunohistochemical staining of normal pancreas specimens for HIF-1α: E, the euglycemic group and F, the hyperglycemic group.
