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Effects of hyperglycemia on microenvironment hypoxia in pancreatic cancer. A, Immunohistochemistry was performed to compare the expression of Hypoxyprobe-1 and HIF-1α in the euglycemic group and hyperglycemic group of orthotopic nude mice. B, The protein levels of HIF-1α and MMP-9 in pancreatic tumor tissues with different serum glucose levels were analyzed using Western blotting. *P < .05 compared to the euglycemic group.
