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. 2018 Oct 16;9:2330. doi: 10.3389/fimmu.2018.02330

Figure 3.

Figure 3

Establishment of eosinophilic chronic rhinosinusitis (ECRS) in WT and IFNAR1 knockout (Ifnar1−/−) mice. (A) Chronic eosinophilic inflammation in the sinonasal mucosa induced by intranasal challenge with Aspergillus oryzae protease (AP) and ovalbumin (OVA) was not complete in the absence of type I IFN signaling. Unlike the wild-type counterpart, epithelial hyperplasia, and inflammatory cells, in particular the eosinophils, definite infiltration was not observed in Ifnar1−/− AP + OVA challenged mice on hematoxylin and eosin (left) and Sirius red (right) staining for eosinophil (magnification, ×400; scale bar, 50 μm). (B,C) Eosinophil number and maximal mucosal thickness were less in Ifnar1−/− AP + OVA challenged mice than in WT AP + OVA challenged mice. **P < 0.01; ***P < 0.001, repeated measurement ANOVA with Tukey's multiple comparison test (B,C).