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. 2018 Nov 11;12(2):236–244. doi: 10.1016/j.tranon.2018.10.009

Figure 4.

Figure 4

Genomic alterations in the IQGAP2 gene associate with a reduction in DFS. Data were extracted from the TCGA dataset within the cBioPortal database [19], [20]. (A) Deep deletion (homodeletion) and missense mutations in the IQGAP2 gene are indicated. Disease status is also included. Each individual bar represents a single patient. The cohort contains 492 tumors with genomic sequence and gene CNVs determined. Only those patients with IQGAP2 genomic alterations and a limited number of patients without the alterations are shown. (B) DFS in patients with and without IQGAP2 genomic alterations in their tumors was analyzed using Kaplan-Meier survival curve. Statistical analysis was performed using log-rank test. Total#: total number of cases; relap#: number of relapsed cases; MMDFS: median months of disease-free survival; NA: not available. Censored individuals are indicated; the number of censored individuals is the total individuals minus relapsed patients.