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. 2018 Oct 16;9:2352. doi: 10.3389/fimmu.2018.02352

Figure 2.

Figure 2

Serum cytokines and anti-LtxA antibodies during Aa infection and after initiation of antibiotic treatment. (A–J), Serial measurements of TNF-α, IFN-γ, IL-18, IL-1β, IL-17A, GM-CSF, IL-6, IL-8, IL-21, and IL-22 (pg/mL), respectively. (K) Serial quantification of IgG and IgA antibodies to LtxA. Dotted lines mark cut-offs for anti-LtxA positivity, which were established using a cohort of healthy individuals without periodontitis (5). Cytokine and anti-LtxA antibody levels were assayed in triplicate and duplicate, respectively. Mean values are shown. Day 0 marks the diagnosis of Aa endocarditis.