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. 2018 Oct 16;9:1180. doi: 10.3389/fphar.2018.01180

FIGURE 6.

FIGURE 6

Impacts of icariin on STAT3 signaling in PA-treated C2C12 myotubes. (A,B) Effect of icariin (ICA) on STAT3 phosphorylation and SOCS3 protein levels. (C,D) Effect of IL-6-neutralizing antibody (IL-6 Ab) on STAT3 phosphorylation and SOCS3 protein levels. (E,F) Effect of TXNIP knockdown on STAT3 phosphorylation and SOCS3 protein levels. N = 4. ∗∗∗p < 0.001 vs. control (Cont) or scramble control (SC) group; ##p < 0.01, ###p < 0.001, vs. PA or SC/PA group; §p > 0.05 vs. PA group.