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. 2018 Oct 16;9:1180. doi: 10.3389/fphar.2018.01180

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Copyright © 2018 Li, Zhang, Cao, Zhang, Liu, Guo and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impacts of proteasome inhibition on insulin signaling in C2C12 myotubes cotreated with PA and icariin (ICA). (A,B) Effect of MG132 on insulin (INS)-stimulated Akt phosphorylation. (C,D) Effect of MG132 on INS-stimulated GLUT4 translocation on plasma membrane. (E) Effects of MG132 on INS-stimulated 2-deoxy-D-glucose (2-DG) uptake. N = 4. ^∗∗p < 0.01, ^∗∗∗p < 0.001 vs. the indicated group; §p > 0.05 vs. the indicated group.