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. 2018 Oct 16;9:2382. doi: 10.3389/fimmu.2018.02382

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Copyright © 2018 Pepys.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Depletion of circulating SAP by CPHPC (miridesap) in patients with systemic amyloidosis. (A) Serum concentration of SAP immediately before and 6 weeks after starting daily treatment with CPHPC. (B) Sustained depletion of SAP throughout CPHPC treatment. Each line shows the results of serial measurements in an individual patient. Note different scale for SAP concentration compared to (A). From Gillmore et al. (73) with permission of Blackwell Publishing Ltd). In patients without systemic amyloidosis and the associated massive extracellular load of SAP (98), CPHPC (miridesap) treatment reduces plasma SAP concentration to much lower values, for example, mean (SD) 0.25 (0.16) mg/l, in our 5 patients with Alzheimer's disease (112).