Table 4.
Relative normalized mRNA expression levels in brain homogenate from aged and aged POS-treated mice determined using quantitative real-time PCR in comparison to young control animals; mRNA expression of young control mice is 100%; n = 9; mean ± SEM with one-way ANOVA and Bonferroni posttest with ∗ P < 0.05; ∗∗ P < 0.01; ∗∗∗ P < 0.001; results are normalized to the mRNA expression levels of beta 2 microglobulin (B2M) and phosphoglycerate kinase 1 (PGK1).
| Aged | Aged + POS | |
|---|---|---|
| AMP-activated protein kinase (beta subunit) | 66.19∗ ± 6.00 | 72.63 ± 8.38 |
| cAMP response binding protein 1 (CREB1) | 64.27∗∗ ± 4.29 | 63.28∗∗ ± 5.94 |
| Citrate synthase (CS) | 66.75∗ ± 4.92 | 61.35∗∗∗ ± 9.16 |
| Complex I (CI) | 75.16∗ ± 3.34 | 67.53∗∗ ± 7.60 |
| Complex IV (CIV) | 58.89∗∗ ± 5.80 | 60.97∗∗ ± 8.00 |
| Glutathione peroxidase 1 (GPx-1) | 67.65∗ ± 8.76 | 58.78∗∗ ± 8.18 |
| Growth-associated protein 43 (GAP43) | 63.43∗ ± 9.23 | 56.73∗∗ ± 8.13 |
| Sirtuin 1 (Sirt1) | 74.71∗ ± 4.65 | 75.36∗∗ ± 5.99 |
| Superoxide dismutase 2 (SOD2) | 97.23 ± 5.26 | 88.46 ± 10.39 |
| Synaptophysin 1 (SYP1) | 83.23 ± 6.08 | 72.26∗ ± 10.43 |