Table 3.
Concentrations of CD4+ T cell-related cytokines and chemokines in plasma from patients with ANCA-associated vasculitis (AAV) and healthy blood donors (HBD).
| IFN-γ | CXCL9 | IL-4 | CCL22 | IL-23 | IL-17A | CCL20 | |
|---|---|---|---|---|---|---|---|
| AAV n = 33 | 13.6∗ (12.8, 14.6) | 61.5∗∗ (38.9, 79.7) | 6.21 (6.21, 7.19) | 248.1 (171.2, 398.8) | 53.8 (50.3, 57.3) | 7.51 (7.10, 8.44) | 28.6∗∗ (21.4, 39.5) |
| Active AAV n = 7 | 13.6 (12.8, 14.4) | 60.4∗∗ (43.4, 65.0) | 6,21 (4.43, 7.0) | 221.4 (34.9, 248.1) | 52.6 (50.3, 57.3) | 7.92 (7.10, 8.23) | 35.8∗∗ (28.6, 37.2) |
| Inactive AAV n = 26 | 13.8 (12.8, 14.8) | 64.0∗∗ (37.0, 80.1) | 6,66 (6.21, 7.32) | 258.3 (174.8, 507.2) | 53.5 (50.3, 57.3) | 7.46 (7.07, 8.64) | 21.3∗∗ (21.3, 0.434) |
| GPA n = 21 | 13.2 (12.8, 14.4) | 51.8∗∗ (37.0, 69.1) | 7.10 (6.21, 7.55) | 239.9 (190.7, 359.8) | 53.8 (50.9, 57.3) | 7.82 (7.20, 8.64) | 25.3∗∗ (18.5, 35.8) |
| MPA n = 10 | 14.0∗ (12.9, 16.0) | 72.5∗∗ (56.1, 117.4) | 6.21 (5.10, 6.43) | 258.3 (73.3, 647.9) | 53.8 (50.3, 60.9) | 7,05 (7.00, 8.15) | 38.2∗∗ (30.5, 74.1) |
| HBD n = 13 | 12.8 (12.2, 13.2) | 22.1 (19.5, 30.4) | 6.21 (6.21, 7.99) | 252.2 (180.4, 307.5) | 53.8 (50.3, 56.1) | 7.72 (7.20, 8.18) | 16.2 (15.0, 18.1) |
Concentrations are measured in pg/mL. Figures represent median with interquartile ranges. ∗ p ≤ 0.05 and ∗∗ p ≤ 0.01, when compared with HBD.