Table 4.

HRs and 95% CI of DR incidence according to follow-up TBiL changes (μmol/L).

	Variable type	HR∗ (95% CI)	P
Total population (n = 5323)	Continuous variable	0.967 (0.944–0.991)	0.006
	Categorical variable		0.011
	≤−2	1.411 (1.081–1.842)
	−2 to 2	1.00 (Ref)
	≥2	0.858 (0.770–0.947)
Among those with baseline TBiL level ≤ 12.5 μmol/L (n = 2669)	Continuous variable	0.964 (0.931–0.986)	0.037
	Categorical variable		0.003
	≤−2	1.756 (1.217–2.534)
	−2 to 2	1.00 (Ref)
	≥2	0.853 (0.761–0.934)
Among those with baseline TBiL level > 12.5 μmol/L (n = 2654)	Continuous variable	0.969 (0.936–1.003)	0.072
	Categorical variable		0.794
	≤−2	1.059 (0.689–1.626)
	−2 to 2	1.00 (Ref)
	≥2	0.864 (0.451–1.654)

^∗Adjusted for age, marital status, current smoking, current alcohol drinking, BMI, baseline Hb, ALT, baseline prevalence of hypertension and dyslipidemia, control of diabetes, duration of diabetes, and baseline TBiL levels (as continuous variable) in the model.