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. 2018 Oct 16;9:2404. doi: 10.3389/fimmu.2018.02404

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Copyright © 2018 Thorenoor, Umstead, Zhang, Phelps and Floros.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Rescue by exogenous SP-A1 or SP-A2 treatment. (A) Depicts overall survival of infected KO mice after surfactant protein (SPs) treatment. (B) Depicts KO mouse survival after pretreatment with SP-A1 or SP-A2 prior to infection, (C) depicts KO survival after pretreatment with vehicle (Vp) and rescue at the time of infection with SP-A1 or SP-A2, (D) depicts KO survival after pretreatment with SP-A1 or SP-A2 and rescue with SP-A1 or SP-A2 at the time of infection. Mouse survival was monitored for 14 days after infection and treatment. Significant differences are indicated for survival ^*p < 0.05.