Figure 3.
Fluid simulation of a single cell encapsulated in a funnel-shaped confining channel. (a) Representative computation model showing numerical simulations of flow velocity (upper) and pressure (lower) profiles in the confining channel. Shape and position of each cell were computed first using the Hertz’s and Tatara’s theories. (b) Flow resistance Rconfining of a confining channel with a single cancer cell trapped as a function of cell diameter Dcell and penetration length L. (c) Drag force Fdrag acting on a trapped cell per unit inlet hydraulic pressure as a function of cell diameter Dcell and penetration length L.