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. Author manuscript; available in PMC: 2019 Oct 18.
Published in final edited form as: Cell. 2018 Oct 18;175(3):679–694.e22. doi: 10.1016/j.cell.2018.09.004

Figure 2. Soluble Fibers Pectin (PCD) and Fructooligosaccharides, but Not Insoluble Fiber Cellulose (CCD), Induced HCC in T5KO Mice.

Figure 2.

(A-F) PCD-fed mice: (A) serum total bilirubin, (B) ALT, (C) AFP, (D) gross liver (~14% HCC incidence), and hepatic mRNA level of (E) fibrosis and (F) HCC markers.

(G-L) Fructooligosaccharides (FOS)-fed mice: (G) total bilirubin, (H) ALT, (I) AFP, (J) gross liver (~13% HCC incidence), and (K) hepatic fibrosis and (L) HCC markers.

(M-R) Low dose ICD-fed group: (M) total bilirubin, (N) ALT, (O) AFP, (P) gross liver (~16% HCC incidence), and (Q) hepatic fibrosis and (R) HCC markers.

(S-V) CCD-fed group: (S) total bilirubin, (T) ALT, (U) AFP, and (V) gross liver (0% HCC incidence). Red circles represent mice with high serum bilirubin that developed HCC on 6 months feeding of indicated diets. Each dot represents the data from one mouse.