(A-F) PCD-fed mice: (A) serum total bilirubin, (B) ALT, (C) AFP, (D) gross liver (~14% HCC incidence), and hepatic mRNA level of (E) fibrosis and (F) HCC markers.
(G-L) Fructooligosaccharides (FOS)-fed mice: (G) total bilirubin, (H) ALT, (I) AFP, (J) gross liver (~13% HCC incidence), and (K) hepatic fibrosis and (L) HCC markers.
(M-R) Low dose ICD-fed group: (M) total bilirubin, (N) ALT, (O) AFP, (P) gross liver (~16% HCC incidence), and (Q) hepatic fibrosis and (R) HCC markers.
(S-V) CCD-fed group: (S) total bilirubin, (T) ALT, (U) AFP, and (V) gross liver (0% HCC incidence). Red circles represent mice with high serum bilirubin that developed HCC on 6 months feeding of indicated diets. Each dot represents the data from one mouse.