Table 1.

lists the parameter values used in the different simulation conditions.

	TRAIL concentration, σL	Death receptor concentration, σR	Binding association rate constant, ko	Binding dissociation rate constant k−	Duration of TRAIL exposure
Soluble TRAIL	Albeck (modified) 3.8 × 109 [#/cm2]	Szegezdi 2 × 104 [#/cm2]	Albeck (modified) 1.94 × 10−12 [cm2/(# ·s)]	Albeck 1 × 10−3 [s−1]	Continuous
Liposomal TRAIL, no shear, with E-selectin	Mitchell (modified) 2 × 1011 [#/cm2]	Szegezdi (modified) 2 × 109 [#/cm2]	Chang and Hammer (no slip velocity) 9.1 × 10−9 [cm2/(#·s)]	Chang and Hammer (no slip velocity) 320 [s−1]	Continuous
Liposomal TRAIL, shear, with E-selectin (assuming cell adhesion)	Mitchell (modified) 2 × 1011 [#/cm2]	Szegezdi (modified) 2 × 109[#/cm2]	Chang and Hammer (slip velocity) 1 × 10−5 [cm2/(#·s)]	Chang and Hammer (no slip velocity) 320 [s−1]	1 × 10−3[s]
Liposomal TRAIL, shear, without E-selectin	Mitchell (modified) 2 × 1011 [#/cm2]	Szegezdi (modified) 2 × 109[#/cm2]	Chang and Hammer (slip velocity) 1 × 10−5 [cm2/(#·s)]	Chang and Hammer 2.4 × 105[s−1]	Continuous

Table of values used in simulation of TRAIL binding to DRs. Albeck et al. (16), Mitchell et al. (14), Chang and Hammer (25), Szegezdi et al. (26).