Shuang-Huang-Sheng-Bai granule |
Elevation of white blood cells, promotion of the proliferation and differentiation of hematopoietic stem/progenitor cells, and the growth of bone marrow hematopoietic cells, inhibition of tumor cell growth and some immunomodulatory effects |
Patients |
Made from Astragalus membranaceus, Rhizoma polygonati, Rhizoma drynariae, Fructus ligustri lucidi, Radix trichosanthes, and Herba epimedii Main chemical constituents: astragaloside, polysaccharides, naringin, specnuezhenide, and icariin |
Wang L. F. et al., 2017
|
Sheng-Mai injection |
Improvement in quality of life, increase of the cellular immunity |
Patients |
Made from Radix ginseng, Radix ophiopogonis, and Fructus schisandrae chinensis Main chemical constituents: ginsenoside Rg1, ginsenoside Re, ginsenoside Rb1, ophiopogonin D, ophiopogonin D', ophiogonanone A and ophiogonanone B |
Duan et al., 2018
|
Panaxadiol saponins |
Regulation of MEK and ERK protein kinases, C-kit, and GATA-1 transcription factors |
Cyclophosphamide- treated mice |
Derived from Ginseng |
Sun X. et al., 2018
|
Ginsenoside Rg3 |
Induction of apoptosis, inhibition of proliferation, metastasis, and angiogenesis, promotion of immunity |
Patients |
A main compound of Ginseng |
Zhang et al., 2018
|
Dang-Gui-Bu-Xue decoction |
No prevention of myelosuppression in breast cancer patients |
Patients |
Made from Radix astragali and Radix Angelicae sinensis Main chemical constituents: calycosin-7-glucoside, ononin, calycosin, formononetin, Z-ligustilide, astragaloside IV, astragaloside II and astragaloside I |
Hong et al., 2017
|
Dang-Gui-Si-Ni decoction |
Upregulation of thrombopoietin expression |
Myelosuppression model of mice |
Made from Angelica sinensis, Cinnamomi cassia, Paeonia lactiiflora, Tetrapanax papyriferus, Asarum heterotropoides, Glycyrrhiza uralensis and Ziziphus jujuba Main chemical constituents: ferulic acid, paeoniflorin, cinnamic acid, and glycyrrhizic acid |
Chen et al., 2015
|
Icaritin |
Promoting the proliferation and differentiation of hematopoietic stem cells, inhibition of apoptosis and stimulating the expression of granulocyte colony-stimulating factor and thyroperoxidase |
Cyclophosphamide-induced myelosuppression in mice |
Hydrolyzed by icariin |
Sun C. et al., 2018
|
Saponins |
Activation of focal adhesion kinase (FAK) and Erk1/2, inhibition of the cytokine expression |
Myelosuppressive mice |
A main ingredients of Radix Sanguisorbae
|
Chen X. et al., 2017
|
Paeoniflorin and albiflorin |
Increase of the white blood cell counts, attenuation of the atrophy of thymus |
Cyclophosphamide and radiotherapy-induced myelosuppression in animals |
Active constituents derived from the root of P. lactiflora
|
Zhu Y. et al., 2016; Zhu Y.-L. et al., 2016
|
Yi-Qi-Yang-Yin formula |
Anti-oxidation |
Mice after total body irradiation |
Made from Astragalus root, Ginseng, glossy privet fruit, Eclipta alba, Chinese Angelica, Bighead Atractylodes rhizome, Wolfiporia extensa, and Radix Glycyrrhizae Preparata Main chemical constituents: astragaloside, ginsenoside, specnuezhenide, ferulic acid, and glycyrrhizic acid |
Zhang et al., 2017
|
San-Yang-Xue-Dai mixture |
Inhibition of ROS-mediated apoptosis |
Doxorubicin-treated mice |
Made from Sanguis draconis, Radix et Rhizoma Notoginseng, Radix et Rhizoma Glycyrrhizae and Radix Angelicae Sinensis Main chemical constituents: bornyl acetate, dracorhodin, ferulic acid, glycyrrhizic acid, 6-gingerol, ginsenoside Rg1, ginsenoside Rb1 and notoginsenoside R1 |
Chen T. et al., 2017
|
Rutin-enriched coriander extract |
Inhibition of ROS-mediated apoptosis and DNA damage |
Ionizing radiation-induced hematopoietic injury of mice |
Phenolic acids (caffeic acid, protocatechinic acid, and gentisic acid), glycitin, and pyrogallol |
Han et al., 2017a
|
Theaflavin |
Anti-oxidation via the Nrf2 pathway |
Ionizing radiation-induced HSC injury in mice |
Tea pigments from black tea |
Han et al., 2017b
|
Astaxanthin |
Anti-oxidation, activation of Nrf2 and anti-oxidative proteins |
Radiation-induced mice |
Found in marine organisms |
Xue et al., 2017
|