Sheng-Mai-San |
Improvement of the syndrome of qi and yin deficiency, heart function and the quality of life of cancer patients |
Patients |
Made from Ginseng radis, Liriope spicata, and Schizandrae fructus Main chemical constituents: ginsenoside Rg, ginsenoside Re and schisandrin |
Lo et al., 2012
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Dan-Hong injection |
Improvement of energy metabolism and reduction of oxidative stress |
Doxorubicin-induced cardiotoxicity in H9c2 cells |
Made from Radix Salviae miltiorrhizae and Flos Carthami tinctorii Main chemical constituents: catechol, tanshinone, salvianic aid A, Carthamin and carthamin yellow |
Yi et al., 2018
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San-Yang-Xue-Dai mixture |
Inhibition of ROS-mediated p53 and MAPK signal pathways |
Doxorubicin-induced cardiotoxicity in mice |
Made from Daemonorops draco, Panax notoginseng, Scoparia dulcis, Aralia cordata, Alpinia ofcinarum, Dioscorea opposita, Wolfporia extensa,and Amomum villosum
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Chen et al., 2018
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Fermented C. sinensis
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Inhibition of myocardial hypertrophy and myocardial damage, Improvement of systolic function, the antioxidant enzyme system, and cardiac energy metabolism, upregulation of the cAMP and AMPK signaling pathways |
Doxorubicin-induced cardiotoxicity in rats |
Protein, carbohydrate, fat, ash, cordycepin, H2O, amino acid, and adenosine |
Wu et al., 2018
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Diethyl blechnic |
Anti-oxidation |
Doxorubicin-induced apoptosis c and primary rat cardiomyocytes |
A main compound isolated from S. miltiorrhiza
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Yu et al., 2018a
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Curcumin |
Upregulation of 14-3-3γ expression |
Doxorubicin-induced cardiotoxicity in mice and primary cardiomyocytes |
Bioactive constituent of Curcuma longa L. |
He et al., 2018
|
Saponin dioscin |
Regulation of miR-140-5p-mediated myocardial oxidative stress |
Doxorubicin-induced cardiotoxicity in H9c2 cells and rats |
Found abundantly in legumes and yams |
Zhao et al., 2018
|
Modified Zhi-Gan-Cao-Tang |
Nourish heart yin and yang, anti-oxidation and inhibition of Na+/K+-ATPase |
Anthracycline-induced congestive heart failure in an 18-year-old adolescent male |
Radix Glycyrrhizae, Radix Ginseng, Fructus Jujubae, Radix Rehmanniae, Radix Ophiopogonis, Colla Corii Asini, Fructus Cannalis, Ramulus Cinnamomi, Rhizoma Zingiberis Recens, Carapax Trionycis, Plastrum Testudinis, Concha Ostreae, and Radix Paeoniae alba
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Wu et al., 2015
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P. grandiflorum |
Anti-oxidation |
Early breast cancer receiving anthracycline-based chemotherapy |
Triterpenoid saponin, carbohydrates, and fibers |
Hao et al., 2017
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Flaxseed oil |
Maintenance of the proper balance between pro-oxidant/antioxidant defense systems |
Arsenic-induced cardiac toxicity in rats |
Polyunsaturated fatty acid alpha-linolenic acid |
Varghese et al., 2017
|
Parsley oil |
Anti-oxidation and anti-inflammation and anti-apoptotic |
Cisplatin-induced hepatic and cardiac injuries in rats |
Phenolic compounds, particularly flavonoids (e.g., apigenin, apiin, and 600-acetylapiin), coumarins, furocoumarins, and essential oil components (mainly myristicin and apiol) |
Abdellatief et al., 2017
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Blueberry anthocyanins-enriched extracts |
Anti-oxidation and anti-inflammation |
Cyclophosphamide-induced cardiac injury in rats |
3-glycosidic derivatives of cyanidin, delphinidin, malvidin, petunidin, and peonidin |
Liu et al., 2015
|
R. cordifolia |
Anti-oxidation |
Cyclophosphamide-induced cardiac injury in rats |
Alkaloids, flavonoids, saponins, and anthraquinones |
Chandrashekar et al., 2018
|
Black grape juice |
Anti-oxidation |
Whole body γ-irradiation-induced heart toxicity of rats |
Phenolics, flavonoids, tannin, gallic acid, catechin, resveratrol, caffeic acid, ellagic acid, quercetin, kaempferol |
de Freitas et al., 2013
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Sheng-Mai Zingerone |
Decrease of caspase-3 gene expression and the prominent nuclear DNA fragmentation as well as increase of mitochondrial complexes' activities |
Cisplatin- or γ-radiation-induced cardiotoxicity in rats |
A active components of ginger |
Soliman et al., 2018
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Hesperidin |
Inhibition of cellular damage and oxidative stress |
γ-radiation-induced tissue damage in Sprague-Dawley rats |
Isolated from the ordinary orange Citrus aurantium and other species of the genus Citrus |
Pradeep et al., 2012
|