FIGURE 11:

Muscle phenotypes for loss of function for the PP2A catalytic subunit (LET-92) and for the PP2A scaffolding subunit (PAA-1). RNAi was performed beginning from the L1 stage and continuing into adulthood. (A) RNAi for let-92 or paa-1 results in paralyzed folded-over or “jack-knifed” adults. Scale bar, 500 μm. (B) RNAi for let-92 or paa-1 results in highly disorganized A-bands and in some cells, detachment of the myofilament lattice from the muscle cell/basement membrane (indicated by yellow arrows). Four representative examples are shown for each gene. Scale bar, 20 μm.