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. 2018 Aug 8;29(16):1927–1940. doi: 10.1091/mbc.E18-03-0164

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© 2018 Li et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 3: — Src and β1 integrin play crucial roles in flow-induced STAT3/6 activation. (A, B) Representative Western blot images (A) and quantification (B) showing that the treatment of macrophages with Src inhibitor PP2 (20 μM) abolished flow-induced STAT3 Tyr705 and STAT6 Tyr641 phosphorylation compared with DMSO control. (C, D) Representative Western blot images (C) and quantification (D) showing that anti-β1 integrin neutralizing antibody (15 μg/ml) decreased flow-induced STAT3 Tyr705 and STAT6 Tyr641 phosphorylation compared with IgG isotype (15 μg/ml) control. Bars represent mean ± SEM of data (fold change relative to no-flow/DMSO control or no-flow/IgG control; n = 3).