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. 2018 Aug 8;29(16):2012–2023. doi: 10.1091/mbc.E18-04-0266

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© 2018 Jahed et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 2: — Structural models of SUN2_413–731 in monomeric and trimeric states. (A) Predicted homology models of SUN2 monomer using Phyre2 with various conformations. Confidence of prediction is shown for residues 413–731. The stars represent the two conformations that were used in this study. (B) Selected homology models of SUN2_413–731 monomers with two distinct conformations (SUN2_M1_413–731 and SUN2_M2_413–731, shown with brown and orange stars, respectively); these models showed no structural overlap with neighboring monomers when assembled into a trimer. Side and top views of the trimeric models are also shown (SUN2_T1_413–731 and SUN2_T1_413–731). (C) Schematic representation of structural models of SUN2_M1_413–731 (brown star) and SUN2_M2_413–731 (orange star) used in this study, for comparison.