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. 2018 Aug 8;29(16):2012–2023. doi: 10.1091/mbc.E18-04-0266

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© 2018 Jahed et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 7: — EDMD-related residue (E452) binds to Ca²⁺ ion and regulates the conformation of CC1-CC2-SUN domain. (A) Electrostatic interactions between calcium ion and residue E452, compared with nonbonded interactions between E452 and residues 458–731 for SUN2_M1_413–731 (top) and SUN2_M2_413–731 (bottom), showing a negative correlation between these interactions (r = –0.84) (B) Representative image of E452 bound to residues 458–731 in the absence of Ca²⁺ ion (left, 250 ns), and representative image of E452 associated with a Ca²⁺ ion and separated from other domains (right, 750 ns).