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. 2018 Aug 8;29(16):2012–2023. doi: 10.1091/mbc.E18-04-0266

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© 2018 Jahed et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 9: — Hypothetical model of SUN2 arrangement in the NE. (A) Standing model of SUN2 monomer inside the NE, where the KASH-lid of SUN2 is autoinhibited by α₁–α₃ helices, (B) Our hypothetical model of SUN2 monomer in the NE, where CC1 bends at residue E452 into two separate α_-helices, CC1_α1 and CC1_α2. Additionally, in this model, the KASH-lid is not autoinhibited. E452 (shown in red) is involved in the monomer–trimer transition and mediates the association of the SUN domain with the CC regions of SUN2 through Ca²⁺ binding.