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Schematic model for WDR62-mediated TNFα-dependent JNK activation. Following TNFα binding to TNF receptor, WDR62 recruits MLK3, MKK7, and JNK to TRAF2, allowing efficient activation of JNK by TNFα. Another scaffold protein mediating the TRAF2/TAK1/JNK axis is yet to be determined. Red circles represent phosphorylation.
