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. 2018 Oct 23;115(45):11625–11630. doi: 10.1073/pnas.1813205115

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Copyright © 2018 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 2. — Newborn neurons are lost in 2-mo SAMP8 animals. (A) Pulse-chase experimental design using BrdU. Animals were killed at 2 h (2h), 1 d (1d) and 3 d (3d) after BrdU injection. (B) BrdU+ cells at the chase time points after injection. SAMP8 animals show a reduction at 3 d vs. SAMR1 (*P < 0.05). SAMR1 animals show an increase over time (^##P < 0.01). (C and D) BrdU+ radial NSCs (C) and BrdU+ NR progenitors (D) at different chase time points. Neither radial NSCs nor NR cells show differences in temporal dynamics. (E) BrdU+DCX+ newborn neurons at all chase time points. SAMP8 strain shows a reduction in this population at 3 d compared with SAMR1. (F) Active Casp3+ cells at 3 d after BrdU injection, showing an increase in cell death in the DG of 2-mo SAMP8 vs. SAMR1.