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. 2018 Oct 23;115(45):11625–11630. doi: 10.1073/pnas.1813205115

Fig. 3.

Fig. 3.

Newborn neurons of 2-mo SAMP8 animals fail to undergo proper maturation. (A) Representative images of the altered number and location of DCX+ cells in 2-mo SAMP8 vs. SAMR1. Arrows indicate DCX+ cells with altered location in SAMP8 GCL. (Scale bar, 25 μm.) (B and C) Number of DCX+ cells (B) and analysis of their location (C). In control animals, DCX+ cells were mainly confined to the innermost (first) third of the DG. SAMP8 animals showed an increased number and abnormal location of this cell population. (D) Number of DCX+CR+ cells at 2 mo, showing a decrease in SAMP8. (E and F) Number of NeuN+BrdU+ mature neurons (E) and S100β+BrdU+ mature astrocytes (F) 3 wk after BrdU injection. SAMP8 animals generate fewer mature neurons and more mature astrocytes. (Right) Image showing a SAMP8 S100β+BrdU+ mature astrocyte, as an example. (Scale bar, 10 µm.) *P < 0.05, **P < 0.01.