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. 2018 Oct 23;115(45):11625–11630. doi: 10.1073/pnas.1813205115

Fig. 4.

Fig. 4.

BMP6 levels are increased in the DG of SAMP8 mice. (A) Heat map showing the mRNA levels (a.u.) of BMP-related signaling components in the DG of 2-mo, 6-mo, and 10-mo SAMR1 and SAMP8. (B) Bmp4 and (C) Bmp6 mRNA expression is significantly increased in 2-mo SAMP8 vs. SAMR1. (D–F) Western blot and densitometry analysis of 2-mo DG lysates (D) showing an increased content in BMP6 normalized to β-actin (E) and P-SMAD1/5/8 normalized to total SMAD1/5/8 (F) in 2-mo SAMP8 vs. SAMR1. *P < 0.05, **P < 0.01, ##P < 0.01.