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. 2018 Oct 22;115(45):E10758–E10767. doi: 10.1073/pnas.1802053115

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Fig. 4. — Genetic ablation of AMPKα1 in Kiss1 neurons prevents pubertal delay induced by subnutrition. A summary is presented of different markers of pubertal onset in mice with genetic ablation of the AMPKα1 subunit in Kiss1-expressing cells (Kiss1-Cre^+/−; AMPKα1 ^loxP/loxP, named KAMKO), and their corresponding Kiss1-Cre^−/−; AMPKα1 ^loxP/loxP controls. The animals were explored in two metabolic conditions: fed ad libitum (normal nutrition; NN) and after chronic subnutrition (20% reduction in daily food ration from PND23 onwards; UN). Data on evolution of BW (A) and percentage of VO (B), as well as final BW (C), VO (D), ovarian weight (OW) (E), and circulating LH levels (F) on PND44, are also shown. Group sizes were: NN-control = 9; NN-KAMKO = 8; UN-control = 10; UN-KAMKO = 9 animals per group. *P < 0.05 vs. corresponding control group (ANOVA followed by Student–Newman–Keuls multiple range test).