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. 2018 Nov 13;8:16750. doi: 10.1038/s41598-018-34755-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DRG microinjection of miR-182 agomir attenuates mechanical hypersensitivity in spared nerve injury rats. (A) Treatment with miR-182 agomir significantly attenuated the SNI-induced mechanical pain on ipsilateral side. (B) And with no effect on contralateral side. Two-way ANOVA followed by post hoc Tukey, F_1,8 = 11.70 in ipsilateral side, F_1,8 = 2.658 in contralateral side (C) miR-182 antagomir induced pain in normal rat on ipsilateral side. (D) And with no effect on contralateral side. Two-way ANOVA followed by post hoc Tukey, F_3,5 = 14.26 in ipsilateral side, F_3,5 = 0.3517 in contralateral side, **P < 0.01 vs. the baseline. n = 6 for each treatment.