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. 2018 Nov 13;8:16750. doi: 10.1038/s41598-018-34755-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DRG microinjection of miR-182 agomir relieved abnormal increased Nav1.7 mRNA and protein level in spared nerve injury rats. (A) Administration with miR-182 agomir alleviated abnormal SCN9A mRNA level. One-way ANOVA followed by post hoc Tukey, F_6,14 = 380.73 for SCN9A expression, F_6,14 = 78.917 for miRNA-182 expression (B) as well as Nav1.7 protein expression in L4-6 DRGs of spare nerve injury rats. One-way ANOVA followed by post hoc Tukey, F_3,8 = 57.584, **P < 0.01 vs. naive group; ^##P < 0.01 vs. the SNI group. n = 3 for each treatment.