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. 2018 Nov 13;8:16750. doi: 10.1038/s41598-018-34755-3

Figure 6.

Figure 6

miR-182 treatment reduces SNI-induced abnormal excitability in L4 and L5 DRG small neurons of rats. (A) Resting membrane potential of small DRG neurons before SNI or after 7 days SNI with or without miR-182 agomir treatment. *P < 0.05 vs. sham and ##P < 0.01 vs. SNI-scramble by two-tailed unpaired Student’s t-test. (B) Rheobase for action potentials of small DRG neurons before SNI or after 7 days SNI with or without miR-182 agomir treatment. n = 10, 7 and 6 neurons from Sham (5 rats), SNI-Scramble (5 rats), and SNI-miR182 groups (3 rats). *P < 0.05 vs. sham and #P < 0.05 vs. SNI-scramble by two-tailed unpaired Student’s t-test. (C) Numbers of evoked action potentials from the Sham, SNI-Scramble and SNI-miR-182 group after application of different currents. Two-way ANOVA followed by post hoc Tukey test, Fgroup (2, 20) = 76.24, *P < 0.05, **P < 0.01 vs. the same stimulation intensity in the SNI-miR-182 group. (D) Representative traces of evoked action potentials.