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. 2018 Nov 13;8:16743. doi: 10.1038/s41598-018-35106-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ME1 copy number amplification associates with ME1 expression and BLBC subtype. (a) Analysis of TCGA dataset for the CNVs of ME1 and TCGA. The relative CNV of ME1 was plotted against that of KRAS. Correlations were analyzed using Spearman’s rank correlation test. (b) Expression of ME1 and KRAS in T47D cells was analyzed by western blotting. (c) Box-plots indicated the association of ME1 expression with its copy number status (gain or no gain) in breast cancer from MEBTABRIC dataset. (d) Analysis of MEBTABRIC dataset for the association of copy number status of ME1 and tumor subtype. (e) Box-plots indicated the association of ME1 expression with its copy number status (gain or no gain) in breast cancer from TCGA dataset. (f) Analysis of TCGA dataset for the association of copy number status of ME1 and tumor subtype. (g) Box-plots indicated the association of ME1 expression with its copy number status (gain or no gain) in breast cancer from CCLE dataset. (h) Analysis of CCLE dataset for the association of copy number status of ME1 and tumor subtype.