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. 2018 Nov 13;8:16743. doi: 10.1038/s41598-018-35106-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Knockdown of ME1 suppresses tumorigenicity. (a) Scatter dot-plot indicated ME1 expression in different tumor size of breast cancer from NKI295 dataset. (b–d) Scatter dot-plots indicated ME1 expression in three histological grades of breast cancer from GSE25066 (b), NKI295 (c) and GSE1456 (d) datasets. (e) Analysis of the relationship between ME1 expression and metastasis. (f) SUM159 cells with stable empty vector or knockdown of ME1 expression were injected into the mammary fat pad of female SCID mice. The growth of breast tumors was monitored. Mice were sacrificed after 30 days. Tumor size and weight were measured and recorded. Data were presented as mean ± SEM from six mice.