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. 2018 Nov 13;8:16764. doi: 10.1038/s41598-018-35261-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Associations between HDL-C levels at sepsis vs. genetic variations per genes analyzed. Plots represent the corrected P value (Benjamini-Hochberg correction with a false discovery rate cutoff of 0.05) per each variant. X-axis: genetic variations analyzed per gene; Y-axis: P values (−log₍₁₀₎) per each genetic variant; The horizontal dotted line represents the −log₍₁₀₎ for the corrected P value of 0.05. The candidate variant rs1800777 was the only one that showed a statistically significant association with HDL-C levels measured at sepsis admission (P = 0.042). Some plots represent overlapped P values of 2 or more genetic variants.