Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Nov 13;8:16764. doi: 10.1038/s41598-018-35261-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Mendelian Randomization Results. (a) Inverse-variance weighting (IVW) analysis including the selected SNPs rs4149346 (ABCA1), rs1800777 (CETP), and rs3213497 (GALNT2). X-axis: changes in HDL-C (mg/mL) per allele change; Y-axis: changes in natural logarithm (ln) odds per allele change. Estimated effects on acute kidney injury (AKI) risk are plotted against estimated effects on serum HDL-C for 3 SNPs associated with HDL-C and AKI. IVW estimate: red solid lines; 95% CI: red dashed lines. SNPs associated with increased HDL-C levels decreased the risk of AKI by 11% (ln = −0.11, odds = 0.89) per 1 mg/dL increases in HDL-C, P = 0.00085). (b) Pleiotropy Analysis: no unbalanced pleiotropy in the IVW MR analysis was found (P = 0.61) as the intercept was not difference from 0. A negative (but less significant) effect of HDL-C on AKI was demonstrated: the risk of AKI decreased by 14% (ln = −0.15, odds = 0.86) per 1 mg/dL of increases in HDL-C (P = 0.11).