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. 2018 Nov 13;8:16745. doi: 10.1038/s41598-018-35199-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of sensor performance in serum and blood. (a) Bode phase and magnitude plot for human serum. (b) Bode phase and magnitude plot for whole blood. (c) Nyquist plot for human serum. (d) Nyquist plot for whole blood. (e) Calibration dose response of cortisol spiked in serum plotted as change in imaginary impedance (Zimg) from baseline. (f) Calibration dose response study for cortisol spiked in whole blood, (g,h) Statistical analysis for significance in impedance change from baseline for (g) serum and (h) whole blood.