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. 2018 Nov 13;8:16716. doi: 10.1038/s41598-018-34699-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PLC nerve guide characteristics. (A) SEM images of the PCL guide with more defined number of micro channels; (B) individual channel dimensions traced in ImageJ to calculate the porosity; (C) randomly oriented PLLA fibers; and (D) aligned PLLA fibers, indicating the porosity of the scaffold, and (E) the Fourier spectra of the random and aligned fibers. (F) SEM image of the PLLA nerve guide, where the pores appear to be less well defined than in the PCL guide; (G) the PCL nerve guide inserted in its silicone shell; (H) explanted nerve guide integrated in the regenerating sciatic nerve; (I) hollow tube bridged by a thin silicone matrix; (J) the regenerated matrix measured to the length of the sciatic nerve defect of 10 mm.