Table 1.

Clinical information and survey rate of each examination.

Age (years)	27.0 (3–63)	14.8 (1–70)	0.002†
Gender	F:M 11:13	F:M 23:29	n.s.††
Follow-up period, months (range)	107.7 (4–457)	17.0 (2–33)	<0.001†
Intellectual functions			n.s.‡
Normal	12	25
Moderate impairment	4	4
Severe impairment	4	23
n/a	4	0
Loss to follow-up	10 (41.7%)	0 (0%)	n/a
Survey of each examination (per month) [mean (range)]
Dermatological visual inspection	0.0036 (0–0.02)	0.074 (0–0.5)	<0.001†
Brain CT/MRI/ultrasonography	0.018 (0–0.25)	0.091 (0–0.5)	0.0104†
Renal MRI/CT/ultrasonography	0.005 (0–0.02)	0.079 (0–0.5)	<0.001†
Ultrasonography/CT	0.003 (0.−0.02)	0.068 (0–0.5)	0.014†
Lung CT	0.003 (0–0.02)	0.025 (0–0.5)	0.001†
Dental visual inspection	0 (0)	0.067 (0–0.5)	<0.001†
Genetic test	0.00008(0–0.02)	0.027(0–0.5)	<0.001†
Fundus examination	0.001 (0–0.02)	0.029 (0–0.33)	0.0035†

TSC: tuberous sclerosis complex; n.s.: not statistically significant; CT: computed tomography; MRI: magnetic resonance image; IF: intellectual function; Normal level: ≥70 full intellectual quotient (IQ) of Wechsler Adult Intelligence Scale III, Wechsler Intelligence Scale for Children, developmental quotient (DQ), or patients who were verbal and independent in their lives,Moderate impai rment level: full IQ ≥ 50 and < 70, DQ ≥ 30 and < 70, or patients who were verbal but dependent on others in their lives; Severe impairment level: < 50 in IQ, < 30 in DQ, or non-verbal and dependent on others in their lives. ^†Welch t-test, ^††Fisher exact test, ^‡Mann-Whitney U-test; n/a: not applicable.

Numbers of patients, sex, age, and follow-up period of the pre- and post-tuberous sclerosis complex board (TB) groups are shown. This table also shows a comparison of the survey rate for each specialty between pre- and post-TB patients. The numbers in the survey of each examination were obtained by dividing the number of inspections by the follow-up period. That is, they show how many examinations were performed per month.