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. 2018 Nov 13;8:16767. doi: 10.1038/s41598-018-35175-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Change in serum uric acid levels according to treatment groups (group without fenofibrate vs. with fenofibrate). Gray dotted lines indicate the reduced levels of uric acid in patients administered allopurinol or febuxostat; blue line indicates the reduced levels of uric acid in the patients co-administered with fenofibrate. The interaction effect on the uric acid levels between treatment groups and whether with or without treatment was not statistically significant (p = 0.084).